Informatics Publishing Limited

S. Lakshmana Prabu ¹, N. Sivagurunathan ¹, C. Dinesh Kumar ¹, S. G. Vasantharaju ¹, B. Meenashi Vanathi ²

Affiliations
1 Manipal College of Pharmaceutical Sciences, Manipal University, Manipal- 576104, Karnataka, IN
2 Shree Devi College of Pharmacy, Mangalore, Karnataka, IN

Abstract

A simple, rapid and accurate RP-HPLC method was developed for the determination of racecadotril in solid pharmaceutical dosage form. The method showed a linear response for concentrations in the range 10-200 μg/ml using methanol: water (80:20 v/v) as the mobile phase with detection at 231 nm and a flow rate of 1.2 ml/min. Solution concentrations were measured at a weight basis to avoid the use of an internal standard. The method was statistically validated for accuracy, precision, linearity, range, ruggedness, robustness, forced degradation, solution stability, and selectivity. Quantitative and recovery studies of the dosage form were also carried out and analyzed; the % RSD from recovery studies was found to be 0.53. Due to the simplicity, rapidity and accuracy of the method, we believe that the method will be useful for routine quality control analysis.

Keywords

Racecadotril, HPLC, Degradation Studies.

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C. Dinesh Kumar ¹, V. Kumaresh ¹, J. Abhimanyu ¹, M. Vasudevan ¹

Affiliations
1 Department of Civil Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Erode-638401, T.N., IN

Abstract

Soil erosion, a complex phenomenon impacting the general land topography, essentially involves distinguishable stages such as detachment and transport of soil particles, storage and runoff of rainwater, and infiltration. Adoption of sustainable soil conservation measures suitable to the land use pattern are of great importance to arrest soil erosion. The present study deals with identifying the critical parameters affecting erosion from a cultivable farm land located in the southern rain-shadow area of Nilgiri Hills at Sathyamangalam. A series of rainfall simulations were performed under laboratory setup by varying rainfall intensity, soil texture, and conservation measures. Three types of soil conservation measures were practiced and tested for understanding water holding capacity and soil and erodability of the collected native soil. Results showed that mulching with dry leaves and growing of deep ischolar_main vetiver plants could give relatively good and comparable results in terms of soil moisture content and percentage of fine particles retained. However, the soil treated with dry sludge collected from co-composting of faecal matter resulted in highest retention of soil moisture as well as fine particles. This can be attributed to the presence of higher organic matter present in the sludge which has the ability to absorb and hold water. Additionally, the soil amended with dry sludge is expected to improve the productivity of land, thereby minimizing the supply of artificial fertilizers. It can be concluded that erosion control by co-composted-dried sludge can be employed as a sustainable alternative for simultaneous erosion control and productivity enhancement of agricultural soil.

Keywords

Co-Composting, Mulching, Soil Conservation, Soil Erosion, Sludge, Vetiver Grass.

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